You can use Ctrl-Shift-A to align to a reference's position. You can also use Ctrl-A to align to its rotation.
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Alt-Q will clear your current snap reference.
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Pressing mouse button 4 while moving/rotating a reference will slow the translation down, allowing for fine movements.
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Alt-G will enable Local Rotation mode, which allows you to move on the world's axis and rotate on the last selected reference's local axis.
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You can double-click a layer to hide/show it.
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You can alt-double-click a layer to freeze it.
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You can ctrl-double-click a layer to make it the active layer.
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You can rotate a group of objects around their local axis by being in Local Mode (G) and holding the control key while rotating the references.
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To make a Static Collection, select the references and press Alt-O. Alt-U will break them back out into their individual statics.
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You can use Ctrl-G to group the selected references. Ctrl-U will ungroup them. You can select a specific reference in a group while holding the alt key.
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To link one reference to another, you can use ctrl-space and click the ref you'd like to link to, then hit enter.
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Alt-Shift-1 will hide all unselected references, which "isolates" the selected references.  Alt-1 will unhide everything.
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You can now use 1 to hide selected triangles while in navmesh mode.  Alt-1 will unhide all hidden triangles.
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You can change the colors of objects and categories in the Object Window by modifying their layout. You can even hide them! Go to View->Object Window Layout
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You can create a Pack-In of references (a saved copy of them) by selecting the references, right clicking, and selecting "Create Pack-In".
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Ctrl-Alt-D will duplicate the selected reference, and LinkRef the old reference to the newly created one.  Quick way to make a patrol, or LinkRef chain.
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While holding Z, X, or C to rotate/move a reference on a specific axis you can manipulate the selected references without actually having your cursor over them.
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Holding S while clicking and dragging will scale a spline's thickness.  Holding Ctrl-Alt-S will adjust its tension.
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If performing operations in the Render Window feels sluggish, and there are a lot of loaded references, try checking the "Filtered Only" checkbox in the "Cell View" window.
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Shift-R will Show/Hide Roombounds and Portals.
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Ctrl-F5 will export data from most lists in the editor to a .txt file.
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Ctrl-Shift-Drag Select will de-select any selected reference.
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The Layer Window now has a Filter Box.
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There is a "Recent Cells" list that displays your most recently visited cells.  You can find it between "Interiors" and "Commonwealth" in the "World Space" drop-down in the "Cell View" window.
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Double right-clicking on an item in most drop-down menus will open that item.
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If you want to stay in the "Recent Cells" Worldspace upon loading a cell then set bSelectWorldspaceForRecentCell=0 under [General] in your CreationKitCustom.ini
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You can now rename multiple forms in the Object Window by selecting them, right clicking, and selecting "Rename".
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The "Out of Date Dialogue" button allows you to record all your dialog quickly.
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In the Scene View, "Dialog Only" allows you to quickly edit dialog.
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In Scene View, Ctrl-P adds a new PC Response.
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In Scene View, Ctrl-D adds a new Dialog Action.
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In Scene View, Ctrl-R adds a new NPC Response Action.
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If you're not in the scene view, if you hold down shift and double left click you can immediately begin editing dialog.
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